E3 ubiquitin-protein ligase ZSWIM2
Intramolecular
Cysteine 234 and cysteine 237
Cysteine 234 and cysteine 261
Cysteine 249 and cysteine 252
Cysteine 234 and cysteine 258
Cysteine 237 and cysteine 261
Cysteine 237 and cysteine 258
Cysteine 258 and cysteine 261
Cysteine 234 and cysteine 246
Cysteine 234 and cysteine 266
Cysteine 261 and cysteine 266
Cysteine 246 and cysteine 258
2dip A 34 A 37
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 234 and 237 (34 and 37 respectively in this structure).
Details
Redox score ?
87
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
16
Peptide accession
Q8NEG5
Residue number A
234
Residue number B
237
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 234 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 237 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 34 A 61
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 234 and 261 (34 and 61 respectively in this structure).
Details
Redox score ?
86
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
19
Peptide accession
Q8NEG5
Residue number A
234
Residue number B
261
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 234 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 261 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 49 A 52
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 249 and 252 (49 and 52 respectively in this structure).
Details
Redox score ?
84
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
8
% buried
6
Peptide accession
Q8NEG5
Residue number A
249
Residue number B
252
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 249 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 252 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 34 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 234 and 258 (34 and 58 respectively in this structure).
Details
Redox score ?
83
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
6
% buried
24
Peptide accession
Q8NEG5
Residue number A
234
Residue number B
258
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 234 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 258 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 37 A 61
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 237 and 261 (37 and 61 respectively in this structure).
Details
Redox score ?
77
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
9
% buried
7
Peptide accession
Q8NEG5
Residue number A
237
Residue number B
261
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 237 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 261 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 37 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 237 and 258 (37 and 58 respectively in this structure).
Details
Redox score ?
76
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
12
Peptide accession
Q8NEG5
Residue number A
237
Residue number B
258
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 237 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 258 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 58 A 61
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 258 and 261 (58 and 61 respectively in this structure).
Details
Redox score ?
74
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
9
% buried
16
Peptide accession
Q8NEG5
Residue number A
258
Residue number B
261
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 258 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 261 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 34 A 46
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 234 and 246 (34 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
37
Peptide accession
Q8NEG5
Residue number A
234
Residue number B
246
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 234 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 246 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 34 A 66
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 234 and 266 (34 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
14
Peptide accession
Q8NEG5
Residue number A
234
Residue number B
266
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 234 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 266 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 61 A 66
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 261 and 266 (61 and 66 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
5
Peptide accession
Q8NEG5
Residue number A
261
Residue number B
266
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 261 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 266 of E3 ubiquitin-protein ligase ZSWIM2
2dip A 46 A 58
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase ZSWIM2 between cysteines 246 and 258 (46 and 58 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
2dip
Structure name
solution structure of the zz domain of zinc finger swim domain containing protein 2
Structure deposition date
2006-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
9
% buried
34
Peptide accession
Q8NEG5
Residue number A
246
Residue number B
258
Peptide name
E3 ubiquitin-protein ligase ZSWIM2
Ligandability
Cysteine 246 of E3 ubiquitin-protein ligase ZSWIM2
Cysteine 258 of E3 ubiquitin-protein ligase ZSWIM2
If this tool was useful for finding a disulphide, please cite: