ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Dual specificity protein phosphatase 18

Intramolecular
Cysteine 115 and cysteine 137
A redox-regulated disulphide may form within Dual specificity protein phosphatase 18 between cysteines 115 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2esb
Structure name
crystal structure of human dusp18
Structure deposition date
2005-10-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
10
% buried
66
Peptide accession
Q8NEJ0
Residue number A
115
Residue number B
137
Peptide name
Dual specificity protein phosphatase 18

Ligandability

Cysteine 115 of Dual specificity protein phosphatase 18

Cysteine 137 of Dual specificity protein phosphatase 18

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