a tool for identifying drug-targetable redox-active disulphides

Transient receptor potential cation channel subfamily V member 1

Intramolecular

Cysteine 386 and cysteine 390

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 1 between cysteines 386 and 390.

Details

Redox score ?

73

PDB code

Structure name

cryo-em structure of minimal trpv1 with 2 bound rtx in opposite pockets

Structure deposition date

2021-05-24

Thiol separation (Å)

4

Half-sphere exposure sum ?

49

Minimum pK_a ?

9

% buried

47

Peptide accession

Residue number A

386

Residue number B

390

Peptide name

Transient receptor potential cation channel subfamily V member 1

Ligandability

Cysteine 386 of Transient receptor potential cation channel subfamily V member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 390 of Transient receptor potential cation channel subfamily V member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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