a tool for identifying drug-targetable redox-active disulphides

Transient receptor potential cation channel subfamily V member 3

Intermolecular

Cysteine 75 and cysteine 721

Cysteine 75 and cysteine 731

Intramolecular

Cysteine 721 and cysteine 731

Cysteine 612 and cysteine 619

A redox-regulated disulphide may form between two units of Transient receptor potential cation channel subfamily V member 3 at cysteines 75 and 721.

Details

Redox score ?

68

PDB code

Structure name

mouse trpv3 in cnw11 nanodiscs, open state at 42 degrees celsius

Structure deposition date

2021-04-17

Thiol separation (Å)

6

Half-sphere exposure sum ?

41

Minimum pK_a ?

9

% buried

16

Peptide A name

Transient receptor potential cation channel subfamily V member 3

Peptide B name

Transient receptor potential cation channel subfamily V member 3

Peptide A accession

Peptide B accession

Peptide A residue number

75

Peptide B residue number

721

Ligandability

Cysteine 75 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 721 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transient receptor potential cation channel subfamily V member 3 at cysteines 75 and 731. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

mouse trpv3 in cnw11 nanodiscs, open state at 42 degrees celsius

Structure deposition date

2021-04-17

Thiol separation (Å)

9

Half-sphere exposure sum ?

45

Minimum pK_a ?

9

% buried

31

Peptide A name

Transient receptor potential cation channel subfamily V member 3

Peptide B name

Transient receptor potential cation channel subfamily V member 3

Peptide A accession

Peptide B accession

Peptide A residue number

75

Peptide B residue number

731

Ligandability

Cysteine 75 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 731 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 3 between cysteines 721 and 731.

Details

Redox score ?

67

PDB code

Structure name

structure of human trpv3 in the presence of 2-apb in c2 symmetry (2)

Structure deposition date

2018-09-18

Thiol separation (Å)

5

Half-sphere exposure sum ?

56

Minimum pK_a ?

10

% buried

38

Peptide accession

Residue number A

721

Residue number B

731

Peptide name

Transient receptor potential cation channel subfamily V member 3

Ligandability

Cysteine 721 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 731 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 3 between cysteines 612 and 619. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

45

PDB code

Structure name

cryo-em structure of mouse trpv3-y564a in open state at 37 degrees celsius

Structure deposition date

2019-07-21

Thiol separation (Å)

10

Half-sphere exposure sum ?

39

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

612

Residue number B

619

Peptide name

Transient receptor potential cation channel subfamily V member 3

Ligandability

Cysteine 612 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of Transient receptor potential cation channel subfamily V member 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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