ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

WD repeat-containing protein 19

Intramolecular
Cysteine 1292 and cysteine 1295
Cysteine 1292 and cysteine 1314
Cysteine 1292 and cysteine 1317
Cysteine 1267 and cysteine 1270
Cysteine 1256 and cysteine 1270
Cysteine 1253 and cysteine 1267
Cysteine 1256 and cysteine 1267
Cysteine 1253 and cysteine 1270
Cysteine 1253 and cysteine 1256
Cysteine 1314 and cysteine 1317
More...
Cysteine 1295 and cysteine 1317
Cysteine 1295 and cysteine 1314
Cysteine 669 and cysteine 685
Cysteine 293 and cysteine 297
Cysteine 144 and cysteine 146
Cysteine 236 and cysteine 293
Cysteine 1263 and cysteine 1277
Cysteine 357 and cysteine 434
Cysteine 434 and cysteine 480
A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1292 and 1295.

Details

Redox score ?
90
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
2
% buried
68
Peptide accession
Q8NEZ3
Residue number A
1292
Residue number B
1295
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1292 of WD repeat-containing protein 19

Cysteine 1295 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1292 and 1314.

Details

Redox score ?
90
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
2
% buried
70
Peptide accession
Q8NEZ3
Residue number A
1292
Residue number B
1314
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1292 of WD repeat-containing protein 19

Cysteine 1314 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1292 and 1317.

Details

Redox score ?
87
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
2
% buried
50
Peptide accession
Q8NEZ3
Residue number A
1292
Residue number B
1317
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1292 of WD repeat-containing protein 19

Cysteine 1317 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1267 and 1270.

Details

Redox score ?
86
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
8
Peptide accession
Q8NEZ3
Residue number A
1267
Residue number B
1270
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1267 of WD repeat-containing protein 19

Cysteine 1270 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1256 and 1270.

Details

Redox score ?
83
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
6
Peptide accession
Q8NEZ3
Residue number A
1256
Residue number B
1270
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1256 of WD repeat-containing protein 19

Cysteine 1270 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1253 and 1267.

Details

Redox score ?
83
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
19
Peptide accession
Q8NEZ3
Residue number A
1253
Residue number B
1267
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1253 of WD repeat-containing protein 19

Cysteine 1267 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1256 and 1267.

Details

Redox score ?
82
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
3
Peptide accession
Q8NEZ3
Residue number A
1256
Residue number B
1267
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1256 of WD repeat-containing protein 19

Cysteine 1267 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1253 and 1270.

Details

Redox score ?
81
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
22
Peptide accession
Q8NEZ3
Residue number A
1253
Residue number B
1270
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1253 of WD repeat-containing protein 19

Cysteine 1270 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1253 and 1256.

Details

Redox score ?
74
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
16
Peptide accession
Q8NEZ3
Residue number A
1253
Residue number B
1256
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1253 of WD repeat-containing protein 19

Cysteine 1256 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1314 and 1317.

Details

Redox score ?
74
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
60
Peptide accession
Q8NEZ3
Residue number A
1314
Residue number B
1317
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1314 of WD repeat-containing protein 19

Cysteine 1317 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1295 and 1317.

Details

Redox score ?
70
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
58
Peptide accession
Q8NEZ3
Residue number A
1295
Residue number B
1317
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1295 of WD repeat-containing protein 19

Cysteine 1317 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1295 and 1314.

Details

Redox score ?
64
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
13
% buried
78
Peptide accession
Q8NEZ3
Residue number A
1295
Residue number B
1314
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1295 of WD repeat-containing protein 19

Cysteine 1314 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 669 and 685. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
72
Peptide accession
Q8NEZ3
Residue number A
669
Residue number B
685
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 669 of WD repeat-containing protein 19

Cysteine 685 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 293 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
8bbf
Structure name
structure of the ift-a complex; ift-a1 module
Structure deposition date
2022-10-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
68
Peptide accession
Q8NEZ3
Residue number A
293
Residue number B
297
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 293 of WD repeat-containing protein 19

Cysteine 297 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 144 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
98
Peptide accession
Q8NEZ3
Residue number A
144
Residue number B
146
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 144 of WD repeat-containing protein 19

Cysteine 146 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 236 and 293. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
8bbf
Structure name
structure of the ift-a complex; ift-a1 module
Structure deposition date
2022-10-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
94
Peptide accession
Q8NEZ3
Residue number A
236
Residue number B
293
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 236 of WD repeat-containing protein 19

Cysteine 293 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 1263 and 1277. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
8bbg
Structure name
structure of the ift-a complex; anterograde ift-a train model
Structure deposition date
2022-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
98
Peptide accession
Q8NEZ3
Residue number A
1263
Residue number B
1277
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 1263 of WD repeat-containing protein 19

Cysteine 1277 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 357 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
8bbf
Structure name
structure of the ift-a complex; ift-a1 module
Structure deposition date
2022-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
90
Peptide accession
Q8NEZ3
Residue number A
357
Residue number B
434
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 357 of WD repeat-containing protein 19

Cysteine 434 of WD repeat-containing protein 19

A redox-regulated disulphide may form within WD repeat-containing protein 19 between cysteines 434 and 480. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
19
PDB code
8bbf
Structure name
structure of the ift-a complex; ift-a1 module
Structure deposition date
2022-10-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
97
Peptide accession
Q8NEZ3
Residue number A
434
Residue number B
480
Peptide name
WD repeat-containing protein 19

Ligandability

Cysteine 434 of WD repeat-containing protein 19

Cysteine 480 of WD repeat-containing protein 19

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