ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gap junction gamma-3 protein

Intermolecular
Cysteine 2 and cysteine 2
Intramolecular
Cysteine 60 and cysteine 174
Cysteine 53 and cysteine 180
Cysteine 64 and cysteine 169
Cysteine 64 and cysteine 174
Cysteine 169 and cysteine 174
Cysteine 60 and cysteine 64
Cysteine 64 and cysteine 180
Cysteine 60 and cysteine 169
Cysteine 169 and cysteine 180
More...
Cysteine 53 and cysteine 64
Cysteine 53 and cysteine 169
Cysteine 53 and cysteine 60
Cysteine 60 and cysteine 180
Cysteine 174 and cysteine 180
Cysteine 53 and cysteine 174
A redox-regulated disulphide may form between two units of Gap junction gamma-3 protein at cysteines 2 and 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6l3v
Structure name
the r15g mutant of human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Gap junction gamma-3 protein
Peptide B name
Gap junction gamma-3 protein
Peptide A accession
Q8NFK1
Peptide B accession
Q8NFK1
Peptide A residue number
2
Peptide B residue number
2

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 60 and 174.

Details

Redox score ?
87
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
60
Residue number B
174
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 60 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 53 and 180.

Details

Redox score ?
86
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
53
Residue number B
180
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 53 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 64 and 169.

Details

Redox score ?
85
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
64
Residue number B
169
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 64 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 64 and 174.

Details

Redox score ?
77
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
64
Residue number B
174
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 64 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 169 and 174.

Details

Redox score ?
77
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
169
Residue number B
174
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 169 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 60 and 64.

Details

Redox score ?
71
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
60
Residue number B
64
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 60 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 64 and 180.

Details

Redox score ?
68
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
64
Residue number B
180
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 64 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 60 and 169.

Details

Redox score ?
67
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
60
Residue number B
169
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 60 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 169 and 180.

Details

Redox score ?
66
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
169
Residue number B
180
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 169 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 53 and 64.

Details

Redox score ?
66
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
5
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
53
Residue number B
64
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 53 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 53 and 169.

Details

Redox score ?
61
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
53
Residue number B
169
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 53 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 169 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 53 and 60. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
6
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
53
Residue number B
60
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 53 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 60 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
6l3t
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
60
Residue number B
180
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 60 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 174 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6l3v
Structure name
the r15g mutant of human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
174
Residue number B
180
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 174 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gap junction gamma-3 protein between cysteines 53 and 174. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
6l3u
Structure name
human cx31
Structure deposition date
2019-10-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFK1
Residue number A
53
Residue number B
174
Peptide name
Gap junction gamma-3 protein

Ligandability

Cysteine 53 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Gap junction gamma-3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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