ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Intramolecular
Cysteine 262 and cysteine 308
Cysteine 36 and cysteine 222
Cysteine 60 and cysteine 108
Cysteine 157 and cysteine 214
A redox-regulated disulphide may form within MAM domain-containing glycosylphosphatidylinositol anchor protein 1 between cysteines 262 and 308.

Details

Redox score ?
84
PDB code
5xeq
Structure name
crystal structure of human mdga1 and human neuroligin-2 complex
Structure deposition date
2017-04-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFP4
Residue number A
262
Residue number B
308
Peptide name
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Ligandability

Cysteine 262 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MAM domain-containing glycosylphosphatidylinositol anchor protein 1 between cysteines 36 and 222.

Details

Redox score ?
84
PDB code
5v5w
Structure name
molecular mechanism of mdga1: regulation of neuroligin 2:neurexin trans-synaptic bridges
Structure deposition date
2017-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFP4
Residue number A
36
Residue number B
222
Peptide name
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Ligandability

Cysteine 36 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MAM domain-containing glycosylphosphatidylinositol anchor protein 1 between cysteines 60 and 108.

Details

Redox score ?
83
PDB code
5v5w
Structure name
molecular mechanism of mdga1: regulation of neuroligin 2:neurexin trans-synaptic bridges
Structure deposition date
2017-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFP4
Residue number A
60
Residue number B
108
Peptide name
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Ligandability

Cysteine 60 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MAM domain-containing glycosylphosphatidylinositol anchor protein 1 between cysteines 157 and 214.

Details

Redox score ?
80
PDB code
5xeq
Structure name
crystal structure of human mdga1 and human neuroligin-2 complex
Structure deposition date
2017-04-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFP4
Residue number A
157
Residue number B
214
Peptide name
MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Ligandability

Cysteine 157 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of MAM domain-containing glycosylphosphatidylinositol anchor protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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