a tool for identifying drug-targetable redox-active disulphides

Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Intramolecular

Cysteine 22 and cysteine 24

A redox-regulated disulphide may form within Diphosphoinositol polyphosphate phosphohydrolase 3-alpha between cysteines 22 and 24.

Details

Redox score ?

64

PDB code

Structure name

crystal structure of human diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Structure deposition date

2010-03-29

Thiol separation (Å)

4

Half-sphere exposure sum ?

103

Minimum pK_a ?

9

% buried

100

Peptide accession

Residue number A

22

Residue number B

24

Peptide name

Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Ligandability

Cysteine 22 of Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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