ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Methylcytosine dioxygenase TET1

Intramolecular
Cysteine 594 and cysteine 597
Cysteine 591 and cysteine 594
Cysteine 606 and cysteine 609
Cysteine 609 and cysteine 619
Cysteine 594 and cysteine 624
Cysteine 603 and cysteine 619
Cysteine 603 and cysteine 606
Cysteine 597 and cysteine 624
Cysteine 606 and cysteine 619
Cysteine 591 and cysteine 624
More...
Cysteine 603 and cysteine 609
Cysteine 591 and cysteine 597
A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 594 and 597.

Details

Redox score ?
79
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
594
Residue number B
597
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 594 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 597 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 591 and 594.

Details

Redox score ?
78
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
591
Residue number B
594
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 591 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 594 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 606 and 609.

Details

Redox score ?
77
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
606
Residue number B
609
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 606 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 609 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 609 and 619.

Details

Redox score ?
77
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
609
Residue number B
619
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 609 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 594 and 624.

Details

Redox score ?
77
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
594
Residue number B
624
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 594 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 624 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 603 and 619.

Details

Redox score ?
76
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
603
Residue number B
619
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 603 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 603 and 606.

Details

Redox score ?
76
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
603
Residue number B
606
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 603 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 606 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 597 and 624.

Details

Redox score ?
76
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
597
Residue number B
624
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 597 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 624 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 606 and 619.

Details

Redox score ?
75
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
606
Residue number B
619
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 606 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 619 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 591 and 624.

Details

Redox score ?
75
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
591
Residue number B
624
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 591 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 624 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 603 and 609.

Details

Redox score ?
74
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
40
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
603
Residue number B
609
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 603 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 609 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET1 between cysteines 591 and 597.

Details

Redox score ?
74
PDB code
6asd
Structure name
zinc finger region of human tet1 in complex with cpg dna
Structure deposition date
2017-08-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFU7
Residue number A
591
Residue number B
597
Peptide name
Methylcytosine dioxygenase TET1

Ligandability

Cysteine 591 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 597 of Methylcytosine dioxygenase TET1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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