ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuroligin-2

Intramolecular
Cysteine 487 and cysteine 521
Cysteine 317 and cysteine 328
Cysteine 106 and cysteine 141
A redox-regulated disulphide may form within Neuroligin-2 between cysteines 487 and 521.

Details

Redox score ?
84
PDB code
5xeq
Structure name
crystal structure of human mdga1 and human neuroligin-2 complex
Structure deposition date
2017-04-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFZ4
Residue number A
487
Residue number B
521
Peptide name
Neuroligin-2

Ligandability

Cysteine 487 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 521 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-2 between cysteines 317 and 328.

Details

Redox score ?
84
PDB code
5xeq
Structure name
crystal structure of human mdga1 and human neuroligin-2 complex
Structure deposition date
2017-04-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NFZ4
Residue number A
317
Residue number B
328
Peptide name
Neuroligin-2

Ligandability

Cysteine 317 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroligin-2 between cysteines 106 and 141.

Details

Redox score ?
82
PDB code
5v5v
Structure name
complex of nlgn2 with mdga1 ig1-ig2
Structure deposition date
2017-03-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62888
Residue number A
106
Residue number B
141
Peptide name
Neuroligin-2

Ligandability

Cysteine 106 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of Neuroligin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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