ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukocyte immunoglobulin-like receptor subfamily B member 4

Intramolecular
Cysteine 10 and cysteine 10
Cysteine 49 and cysteine 98
Cysteine 144 and cysteine 195
Cysteine 10 and cysteine 195
Cysteine 144 and cysteine 10
A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 4 between cysteines 10 and 10 (133 and 143 respectively in this structure).

Details

Redox score ?
85
PDB code
3p2t
Structure name
crystal structure of leukocyte ig-like receptor lilrb4 (ilt3/lir- 5/cd85k)
Structure deposition date
2010-10-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHJ6
Residue number A
10
Residue number B
10
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 4

Ligandability

Cysteine 10 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 10 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 4 between cysteines 49 and 98 (26 and 75 respectively in this structure).

Details

Redox score ?
81
PDB code
6k7o
Structure name
complex structure of lilrb4 and h128-3 antibody
Structure deposition date
2019-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHJ6
Residue number A
49
Residue number B
98
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 4

Ligandability

Cysteine 49 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 4 between cysteines 144 and 195 (121 and 172 respectively in this structure).

Details

Redox score ?
81
PDB code
3p2t
Structure name
crystal structure of leukocyte ig-like receptor lilrb4 (ilt3/lir- 5/cd85k)
Structure deposition date
2010-10-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHJ6
Residue number A
144
Residue number B
195
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 4

Ligandability

Cysteine 144 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 4 between cysteines 10 and 195 (133 and 172 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3p2t
Structure name
crystal structure of leukocyte ig-like receptor lilrb4 (ilt3/lir- 5/cd85k)
Structure deposition date
2010-10-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHJ6
Residue number A
10
Residue number B
195
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 4

Ligandability

Cysteine 10 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 4 between cysteines 144 and 10 (121 and 133 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3p2t
Structure name
crystal structure of leukocyte ig-like receptor lilrb4 (ilt3/lir- 5/cd85k)
Structure deposition date
2010-10-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHJ6
Residue number A
144
Residue number B
10
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 4

Ligandability

Cysteine 144 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 10 of Leukocyte immunoglobulin-like receptor subfamily B member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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