ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Leukocyte immunoglobulin-like receptor subfamily B member 1

Intramolecular
Cysteine 49 and cysteine 98
Cysteine 246 and cysteine 297
Cysteine 346 and cysteine 397
Cysteine 145 and cysteine 197
Cysteine 157 and cysteine 167
Cysteine 157 and cysteine 197
Cysteine 145 and cysteine 157
A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 49 and 98 (26 and 75 respectively in this structure).

Details

Redox score ?
83
PDB code
3d2u
Structure name
structure of ul18, a peptide-binding viral mhc mimic, bound to a host inhibitory receptor
Structure deposition date
2008-05-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHL6
Residue number A
49
Residue number B
98
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 49 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 246 and 297 (26 and 77 respectively in this structure).

Details

Redox score ?
82
PDB code
4ll9
Structure name
crystal structure of d3d4 domain of the lilrb1 molecule
Structure deposition date
2013-07-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHL6
Residue number A
246
Residue number B
297
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 246 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Isoform 2 of Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 346 and 397.

Details

Redox score ?
81
PDB code
7kfk
Structure name
crystal structure of lilrb1 d3d4 domain in complex with plasmodium rifin (pf3d7_1373400) v2 domain
Structure deposition date
2020-10-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHL6-2
Residue number A
346
Residue number B
397
Peptide name
Isoform 2 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 346 of Isoform 2 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 397 of Isoform 2 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 145 and 197 (122 and 174 respectively in this structure).

Details

Redox score ?
80
PDB code
1vdg
Structure name
crystal structure of lir1
Structure deposition date
2004-03-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHL6
Residue number A
145
Residue number B
197
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 145 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 157 and 167 (134 and 144 respectively in this structure).

Details

Redox score ?
71
PDB code
5knm
Structure name
human leukocyte antigen f (hla-f) presents peptides and regulates immunity through interactions with nk-cell receptors
Structure deposition date
2016-06-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
50
Peptide accession
Q8NHL6
Residue number A
157
Residue number B
167
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 157 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 167 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 157 and 197 (134 and 174 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5knm
Structure name
human leukocyte antigen f (hla-f) presents peptides and regulates immunity through interactions with nk-cell receptors
Structure deposition date
2016-06-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
nan
Peptide accession
Q8NHL6
Residue number A
157
Residue number B
197
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 157 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 197 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Leukocyte immunoglobulin-like receptor subfamily B member 1 between cysteines 145 and 157 (122 and 134 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
1g0x
Structure name
crystal structure of the ligand binding domain of lir-1 (ilt2)
Structure deposition date
2000-10-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NHL6
Residue number A
145
Residue number B
157
Peptide name
Leukocyte immunoglobulin-like receptor subfamily B member 1

Ligandability

Cysteine 145 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of Leukocyte immunoglobulin-like receptor subfamily B member 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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