ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Two pore channel protein 2

Intermolecular
Cysteine 623 and cysteine 623
Cysteine 450 and cysteine 228
Intramolecular
Cysteine 122 and cysteine 180
A redox-regulated disulphide may form between two units of Two pore channel protein 2 at cysteines 623 and 623.

Details

Redox score ?
88
PDB code
6nq2
Structure name
cryo-em structure of human tpc2 channel in the ligand-bound closed state
Structure deposition date
2019-01-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
36
Minimum pKa ?
nan
% buried
nan
Peptide A name
Two pore channel protein 2
Peptide B name
Two pore channel protein 2
Peptide A accession
Q8NHX9
Peptide B accession
Q8NHX9
Peptide A residue number
623
Peptide B residue number
623

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Two pore channel protein 2 at cysteines 450 and 228. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6nq1
Structure name
cryo-em structure of human tpc2 channel in the apo state
Structure deposition date
2019-01-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
29
Peptide A name
Two pore channel protein 2
Peptide B name
Two pore channel protein 2
Peptide A accession
Q8NHX9
Peptide B accession
Q8NHX9
Peptide A residue number
450
Peptide B residue number
228

Ligandability

Cysteine 450 of Two pore channel protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Two pore channel protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Two pore channel protein 2 between cysteines 122 and 180.

Details

Redox score ?
74
PDB code
6nq2
Structure name
cryo-em structure of human tpc2 channel in the ligand-bound closed state
Structure deposition date
2019-01-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
43
Minimum pKa ?
10
% buried
11
Peptide accession
Q8NHX9
Residue number A
122
Residue number B
180
Peptide name
Two pore channel protein 2

Ligandability

Cysteine 122 of Two pore channel protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Two pore channel protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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