ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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receptor protein-tyrosine kinase

Intramolecular
Cysteine 238 and cysteine 301
Cysteine 139 and cysteine 191
A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 238 and 301 (275 and 338 respectively in this structure).

Details

Redox score ?
82
PDB code
3grw
Structure name
fgfr3 in complex with a fab
Structure deposition date
2009-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NI16
Residue number A
238
Residue number B
301
Peptide name
receptor protein-tyrosine kinase

Ligandability

Cysteine 238 of receptor protein-tyrosine kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 301 of receptor protein-tyrosine kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within receptor protein-tyrosine kinase between cysteines 139 and 191 (176 and 228 respectively in this structure).

Details

Redox score ?
80
PDB code
3grw
Structure name
fgfr3 in complex with a fab
Structure deposition date
2009-03-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8NI16
Residue number A
139
Residue number B
191
Peptide name
receptor protein-tyrosine kinase

Ligandability

Cysteine 139 of receptor protein-tyrosine kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of receptor protein-tyrosine kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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