ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Atypical kinase COQ8A, mitochondrial

Intramolecular
Cysteine 468 and cysteine 620
Cysteine 620 and cysteine 629
Cysteine 475 and cysteine 620
A redox-regulated disulphide may form within Atypical kinase COQ8A, mitochondrial between cysteines 468 and 620.

Details

Redox score ?
64
PDB code
7udq
Structure name
crystal structure of coq8a-ca157 inhibitor complex in space group p1
Structure deposition date
2022-03-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
9
% buried
100
Peptide accession
Q8NI60
Residue number A
468
Residue number B
620
Peptide name
Atypical kinase COQ8A, mitochondrial

Ligandability

Cysteine 468 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Atypical kinase COQ8A, mitochondrial between cysteines 620 and 629. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4ped
Structure name
mitochondrial adck3 employs an atypical protein kinase-like fold to enable coenzyme q biosynthes
Structure deposition date
2014-04-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
91
Peptide accession
Q8NI60
Residue number A
620
Residue number B
629
Peptide name
Atypical kinase COQ8A, mitochondrial

Ligandability

Cysteine 620 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 629 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Atypical kinase COQ8A, mitochondrial between cysteines 475 and 620. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4ped
Structure name
mitochondrial adck3 employs an atypical protein kinase-like fold to enable coenzyme q biosynthes
Structure deposition date
2014-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
100
Peptide accession
Q8NI60
Residue number A
475
Residue number B
620
Peptide name
Atypical kinase COQ8A, mitochondrial

Ligandability

Cysteine 475 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Atypical kinase COQ8A, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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