ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin-like protein KIF18A

Intramolecular
Cysteine 107 and cysteine 324
Cysteine 143 and cysteine 153
A redox-regulated disulphide may form within Kinesin-like protein KIF18A between cysteines 107 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3lre
Structure name
crystal structure analysis of human kinesin-8 motor domain
Structure deposition date
2010-02-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
68
Peptide accession
Q8NI77
Residue number A
107
Residue number B
324
Peptide name
Kinesin-like protein KIF18A

Ligandability

Cysteine 107 of Kinesin-like protein KIF18A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Kinesin-like protein KIF18A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin-like protein KIF18A between cysteines 143 and 153. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
3lre
Structure name
crystal structure analysis of human kinesin-8 motor domain
Structure deposition date
2010-02-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
36
Peptide accession
Q8NI77
Residue number A
143
Residue number B
153
Peptide name
Kinesin-like protein KIF18A

Ligandability

Cysteine 143 of Kinesin-like protein KIF18A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Kinesin-like protein KIF18A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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