ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SWI/SNF complex subunit SMARCC2

Intermolecular
Cysteine 486 and cysteine 24 of Zinc finger protein ubi-d4 L
A redox-regulated disulphide may form between cysteine 486 of SWI/SNF complex subunit SMARCC2 and cysteine 24 of Zinc finger protein ubi-d4. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6ltj
Structure name
structure of nucleosome-bound human baf complex
Structure deposition date
2020-01-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide A name
SWI/SNF complex subunit SMARCC2
Peptide B name
Zinc finger protein ubi-d4
Peptide A accession
Q8TAQ2
Peptide B accession
Q92785
Peptide A residue number
486
Peptide B residue number
24

Ligandability

Cysteine 486 of SWI/SNF complex subunit SMARCC2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 24 of Zinc finger protein ubi-d4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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