ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

DEP domain-containing mTOR-interacting protein

Intermolecular
Cysteine 102 and cysteine 102
Cysteine 1498 of Serine/threonine-protein kinase mTOR and cysteine 304 L
Intramolecular
Cysteine 63 and cysteine 102
A redox-regulated disulphide may form between two units of DEP domain-containing mTOR-interacting protein at cysteines 102 and 102.

Details

Redox score ?
86
PDB code
7ped
Structure name
deptor dep domain tandem (dept)
Structure deposition date
2021-08-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide A name
DEP domain-containing mTOR-interacting protein
Peptide B name
DEP domain-containing mTOR-interacting protein
Peptide A accession
Q8TB45
Peptide B accession
Q8TB45
Peptide A residue number
102
Peptide B residue number
102

Ligandability

A redox-regulated disulphide may form between cysteine 1498 of Serine/threonine-protein kinase mTOR and cysteine 304 of DEP domain-containing mTOR-interacting protein.

Details

Redox score ?
62
PDB code
7pe9
Structure name
cryo-em structure of deptor bound to human mtor complex 2, dept-bound subset local refinement
Structure deposition date
2021-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
25
Peptide A name
Serine/threonine-protein kinase mTOR
Peptide B name
DEP domain-containing mTOR-interacting protein
Peptide A accession
P42345
Peptide B accession
Q8TB45
Peptide A residue number
1498
Peptide B residue number
304

Ligandability

Cysteine 1498 of Serine/threonine-protein kinase mTOR

Cysteine 304 of DEP domain-containing mTOR-interacting protein

A redox-regulated disulphide may form within DEP domain-containing mTOR-interacting protein between cysteines 63 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7dkl
Structure name
crystal structure of the tandem dep domains of deptor
Structure deposition date
2020-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
28
Peptide accession
Q8TB45
Residue number A
63
Residue number B
102
Peptide name
DEP domain-containing mTOR-interacting protein

Ligandability

Cysteine 63 of DEP domain-containing mTOR-interacting protein

Cysteine 102 of DEP domain-containing mTOR-interacting protein

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