ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pumilio homolog 2

Intramolecular
Cysteine 982 and cysteine 983
Cysteine 857 and cysteine 860
Cysteine 844 and cysteine 857
A redox-regulated disulphide may form within Pumilio homolog 2 between cysteines 982 and 983.

Details

Redox score ?
83
PDB code
3q0q
Structure name
crystal structure of the pumilio-homology domain from human pumilio2 in complex with p38alpha nrea
Structure deposition date
2010-12-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TB72
Residue number A
982
Residue number B
983
Peptide name
Pumilio homolog 2

Ligandability

Cysteine 982 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 983 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pumilio homolog 2 between cysteines 857 and 860. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3gvt
Structure name
structure and rna binding of the mouse pumilio-2 puf domain
Structure deposition date
2009-03-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
96
Peptide accession
Q80U58
Residue number A
857
Residue number B
860
Peptide name
Pumilio homolog 2

Ligandability

Cysteine 857 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 860 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pumilio homolog 2 between cysteines 844 and 857. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3q0q
Structure name
crystal structure of the pumilio-homology domain from human pumilio2 in complex with p38alpha nrea
Structure deposition date
2010-12-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
84
Peptide accession
Q8TB72
Residue number A
844
Residue number B
857
Peptide name
Pumilio homolog 2

Ligandability

Cysteine 844 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 857 of Pumilio homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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