Protein cornichon homolog 3
Intermolecular
Cysteine 549 of Glutamate receptor 2 and cysteine 9
Intramolecular
Cysteine 108 and cysteine 131
Cysteine 9 and cysteine 84
Cysteine 61 and cysteine 131
Cysteine 131 and cysteine 137
Cysteine 79 and cysteine 84
Cysteine 9 and cysteine 152
Cysteine 9 and cysteine 79
6ucb C 528 H 9
A redox-regulated disulphide may form between cysteine 549 of Glutamate receptor 2 and cysteine 9 of Protein cornichon homolog 3 (528 and 9 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
6ucb
Structure name
glua2 in complex with its auxiliary subunit cnih3 - with antagonist zk200775, lbd, tmd, cnih3, and lipids
Structure deposition date
2019-09-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide A name
Glutamate receptor 2
Peptide B name
Protein cornichon homolog 3
Peptide A accession
P19491
Peptide B accession
Q6ZWS4
Peptide A residue number
549
Peptide B residue number
9
Ligandability
Cysteine 549 of Glutamate receptor 2
Cysteine 9 of Protein cornichon homolog 3
6peq G 108 G 131
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 108 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6peq
Structure name
glua2 in complex with its auxiliary subunit cnih3 - map lbd-tmd-c3 - with antagonist zk200775 -without ntd
Structure deposition date
2019-06-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
37
Peptide accession
Q6ZWS4
Residue number A
108
Residue number B
131
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 108 of Protein cornichon homolog 3
Cysteine 131 of Protein cornichon homolog 3
6ucb E 9 E 84
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 9 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6ucb
Structure name
glua2 in complex with its auxiliary subunit cnih3 - with antagonist zk200775, lbd, tmd, cnih3, and lipids
Structure deposition date
2019-09-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
76
Peptide accession
Q6ZWS4
Residue number A
9
Residue number B
84
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 9 of Protein cornichon homolog 3
Cysteine 84 of Protein cornichon homolog 3
6peq E 61 E 131
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 61 and 131. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
6peq
Structure name
glua2 in complex with its auxiliary subunit cnih3 - map lbd-tmd-c3 - with antagonist zk200775 -without ntd
Structure deposition date
2019-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
28
Peptide accession
Q6ZWS4
Residue number A
61
Residue number B
131
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 61 of Protein cornichon homolog 3
Cysteine 131 of Protein cornichon homolog 3
6ud4 H 131 H 137
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 131 and 137. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6ud4
Structure name
glua2 in complex with its auxiliary subunit cnih3 in as map ii - (lbd- tmd-c3(as) ii)- with antagonist zk200775, without ntd
Structure deposition date
2019-09-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
41
Minimum pKa ?
10
% buried
33
Peptide accession
Q6ZWS4
Residue number A
131
Residue number B
137
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 131 of Protein cornichon homolog 3
Cysteine 137 of Protein cornichon homolog 3
6peq G 79 G 84
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 79 and 84. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6peq
Structure name
glua2 in complex with its auxiliary subunit cnih3 - map lbd-tmd-c3 - with antagonist zk200775 -without ntd
Structure deposition date
2019-06-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
47
Peptide accession
Q6ZWS4
Residue number A
79
Residue number B
84
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 79 of Protein cornichon homolog 3
Cysteine 84 of Protein cornichon homolog 3
6peq H 9 H 152
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 9 and 152. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6peq
Structure name
glua2 in complex with its auxiliary subunit cnih3 - map lbd-tmd-c3 - with antagonist zk200775 -without ntd
Structure deposition date
2019-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
71
Peptide accession
Q6ZWS4
Residue number A
9
Residue number B
152
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 9 of Protein cornichon homolog 3
Cysteine 152 of Protein cornichon homolog 3
6peq H 9 H 79
A redox-regulated disulphide may form within Protein cornichon homolog 3 between cysteines 9 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6peq
Structure name
glua2 in complex with its auxiliary subunit cnih3 - map lbd-tmd-c3 - with antagonist zk200775 -without ntd
Structure deposition date
2019-06-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
78
Peptide accession
Q6ZWS4
Residue number A
9
Residue number B
79
Peptide name
Protein cornichon homolog 3
Ligandability
Cysteine 9 of Protein cornichon homolog 3
Cysteine 79 of Protein cornichon homolog 3
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