ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ethanolamine-phosphate phospho-lyase

Intramolecular
Cysteine 106 and cysteine 288
Cysteine 106 and cysteine 317
Cysteine 288 and cysteine 317
A redox-regulated disulphide may form within Ethanolamine-phosphate phospho-lyase between cysteines 106 and 288.

Details

Redox score ?
65
PDB code
6tor
Structure name
human o-phosphoethanolamine phospho-lyase
Structure deposition date
2019-12-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
8
% buried
98
Peptide accession
Q8TBG4
Residue number A
106
Residue number B
288
Peptide name
Ethanolamine-phosphate phospho-lyase

Ligandability

Cysteine 106 of Ethanolamine-phosphate phospho-lyase

Cysteine 288 of Ethanolamine-phosphate phospho-lyase

A redox-regulated disulphide may form within Ethanolamine-phosphate phospho-lyase between cysteines 106 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6tor
Structure name
human o-phosphoethanolamine phospho-lyase
Structure deposition date
2019-12-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
89
Minimum pKa ?
8
% buried
98
Peptide accession
Q8TBG4
Residue number A
106
Residue number B
317
Peptide name
Ethanolamine-phosphate phospho-lyase

Ligandability

Cysteine 106 of Ethanolamine-phosphate phospho-lyase

Cysteine 317 of Ethanolamine-phosphate phospho-lyase

A redox-regulated disulphide may form within Ethanolamine-phosphate phospho-lyase between cysteines 288 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6tor
Structure name
human o-phosphoethanolamine phospho-lyase
Structure deposition date
2019-12-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TBG4
Residue number A
288
Residue number B
317
Peptide name
Ethanolamine-phosphate phospho-lyase

Ligandability

Cysteine 288 of Ethanolamine-phosphate phospho-lyase

Cysteine 317 of Ethanolamine-phosphate phospho-lyase

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