ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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WD repeat-containing protein 20

Intramolecular
Cysteine 379 and cysteine 528
Cysteine 550 and cysteine 556
Cysteine 103 and cysteine 154
Cysteine 183 and cysteine 204
Cysteine 267 and cysteine 269
Cysteine 154 and cysteine 237
A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 379 and 528.

Details

Redox score ?
79
PDB code
5k19
Structure name
crystal structure of wd repeat-containing protein 20
Structure deposition date
2016-05-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
7
% buried
69
Peptide accession
Q8TBZ3
Residue number A
379
Residue number B
528
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 379 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 528 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 550 and 556. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5k19
Structure name
crystal structure of wd repeat-containing protein 20
Structure deposition date
2016-05-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
78
Peptide accession
Q8TBZ3
Residue number A
550
Residue number B
556
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 550 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 556 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 103 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5k19
Structure name
crystal structure of wd repeat-containing protein 20
Structure deposition date
2016-05-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
100
Peptide accession
Q8TBZ3
Residue number A
103
Residue number B
154
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 103 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 183 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
5k1c
Structure name
crystal structure of the uaf1/wdr20/usp12 complex
Structure deposition date
2016-05-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
43
Peptide accession
Q8TBZ3
Residue number A
183
Residue number B
204
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 183 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 267 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
5k19
Structure name
crystal structure of wd repeat-containing protein 20
Structure deposition date
2016-05-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TBZ3
Residue number A
267
Residue number B
269
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 267 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 269 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 20 between cysteines 154 and 237. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
26
PDB code
5k19
Structure name
crystal structure of wd repeat-containing protein 20
Structure deposition date
2016-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
100
Peptide accession
Q8TBZ3
Residue number A
154
Residue number B
237
Peptide name
WD repeat-containing protein 20

Ligandability

Cysteine 154 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 237 of WD repeat-containing protein 20

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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