ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Intramolecular
Cysteine 252 and cysteine 253
Cysteine 469 and cysteine 554
Cysteine 251 and cysteine 252
Cysteine 251 and cysteine 253
A redox-regulated disulphide may form within Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B between cysteines 252 and 253. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6s7t
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-b
Structure deposition date
2019-07-05
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TCJ2
Residue number A
252
Residue number B
253
Peptide name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Ligandability

Cysteine 252 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B between cysteines 469 and 554. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6s7t
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-b
Structure deposition date
2019-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TCJ2
Residue number A
469
Residue number B
554
Peptide name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Ligandability

Cysteine 469 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 554 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B between cysteines 251 and 252. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6s7t
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-b
Structure deposition date
2019-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
13
% buried
98
Peptide accession
Q8TCJ2
Residue number A
251
Residue number B
252
Peptide name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Ligandability

Cysteine 251 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 252 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B between cysteines 251 and 253. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
6s7t
Structure name
cryo-em structure of human oligosaccharyltransferase complex ost-b
Structure deposition date
2019-07-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
98
Peptide accession
Q8TCJ2
Residue number A
251
Residue number B
253
Peptide name
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Ligandability

Cysteine 251 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 253 of Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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