ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Intramolecular
Cysteine 372 and cysteine 489
Cysteine 395 and cysteine 489
A redox-regulated disulphide may form within Polyribonucleotide nucleotidyltransferase 1, mitochondrial between cysteines 372 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
3u1k
Structure name
crystal structure of human pnpase
Structure deposition date
2011-09-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
10
% buried
80
Peptide accession
Q8TCS8
Residue number A
372
Residue number B
489
Peptide name
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Ligandability

Cysteine 372 of Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Polyribonucleotide nucleotidyltransferase 1, mitochondrial between cysteines 395 and 489. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3u1k
Structure name
crystal structure of human pnpase
Structure deposition date
2011-09-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
106
Minimum pKa ?
12
% buried
100
Peptide accession
Q8TCS8
Residue number A
395
Residue number B
489
Peptide name
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Ligandability

Cysteine 395 of Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 489 of Polyribonucleotide nucleotidyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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