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Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Intramolecular
Cysteine 200 and cysteine 234
Cysteine 879 and cysteine 968
Cysteine 879 and cysteine 1336
Cysteine 879 and cysteine 972
Cysteine 149 and cysteine 200
Cysteine 972 and cysteine 1336
Cysteine 149 and cysteine 234
Cysteine 901 and cysteine 923
Cysteine 879 and cysteine 1328
Cysteine 1021 and cysteine 1578
More...
Cysteine 968 and cysteine 1328
Cysteine 963 and cysteine 968
Cysteine 1543 and cysteine 1572
Cysteine 1380 and cysteine 1572
Cysteine 968 and cysteine 1336
Cysteine 968 and cysteine 972
Cysteine 1021 and cysteine 1336
Cysteine 972 and cysteine 1021
A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 200 and 234.

Details

Redox score ?
66
PDB code
5fi0
Structure name
crystal structure of the p-rex1 dh/ph tandem in complex with rac1
Structure deposition date
2015-12-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
200
Residue number B
234
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 200 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 879 and 968.

Details

Redox score ?
65
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
105
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
879
Residue number B
968
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 879 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 968 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 879 and 1336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
95
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
879
Residue number B
1336
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 879 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1336 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 879 and 972. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
98
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
879
Residue number B
972
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 879 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 972 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 149 and 200. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5fi0
Structure name
crystal structure of the p-rex1 dh/ph tandem in complex with rac1
Structure deposition date
2015-12-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
149
Residue number B
200
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 149 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 200 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 972 and 1336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
14
% buried
100
Peptide accession
Q8TCU6
Residue number A
972
Residue number B
1336
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 972 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1336 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 149 and 234. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7rx9
Structure name
structure of autoinhibited p-rex1
Structure deposition date
2021-08-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
77
Peptide accession
Q8TCU6
Residue number A
149
Residue number B
234
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 149 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 901 and 923. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
74
Peptide accession
Q8TCU6
Residue number A
901
Residue number B
923
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 901 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 923 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 879 and 1328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TCU6
Residue number A
879
Residue number B
1328
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 879 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1328 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 1021 and 1578. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
96
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TCU6
Residue number A
1021
Residue number B
1578
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 1021 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1578 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 968 and 1328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
101
Minimum pKa ?
14
% buried
100
Peptide accession
Q8TCU6
Residue number A
968
Residue number B
1328
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 968 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1328 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 963 and 968. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
71
Peptide accession
Q8TCU6
Residue number A
963
Residue number B
968
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 963 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 968 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 1543 and 1572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
90
Peptide accession
Q8TCU6
Residue number A
1543
Residue number B
1572
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 1543 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1572 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 1380 and 1572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
13
% buried
100
Peptide accession
Q8TCU6
Residue number A
1380
Residue number B
1572
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 1380 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1572 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 968 and 1336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
99
Minimum pKa ?
14
% buried
100
Peptide accession
Q8TCU6
Residue number A
968
Residue number B
1336
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 968 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1336 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 968 and 972. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
102
Minimum pKa ?
15
% buried
100
Peptide accession
Q8TCU6
Residue number A
968
Residue number B
972
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 968 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 972 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 1021 and 1336. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
93
Minimum pKa ?
14
% buried
100
Peptide accession
Q8TCU6
Residue number A
1021
Residue number B
1336
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 1021 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1336 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein between cysteines 972 and 1021. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
20
PDB code
7syf
Structure name
reconstruction of full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1)
Structure deposition date
2021-11-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
95
Minimum pKa ?
14
% buried
100
Peptide accession
Q8TCU6
Residue number A
972
Residue number B
1021
Peptide name
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Ligandability

Cysteine 972 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1021 of Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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