ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily M member 4

Intramolecular
Cysteine 646 and cysteine 654
Cysteine 993 and cysteine 1011
Cysteine 299 and cysteine 311
Cysteine 867 and cysteine 874
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 4 between cysteines 646 and 654.

Details

Redox score ?
77
PDB code
6bqv
Structure name
human trpm4 ion channel in lipid nanodiscs in a calcium-bound state
Structure deposition date
2017-11-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
7
% buried
87
Peptide accession
Q8TD43
Residue number A
646
Residue number B
654
Peptide name
Transient receptor potential cation channel subfamily M member 4

Ligandability

Cysteine 646 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 654 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 4 between cysteines 993 and 1011.

Details

Redox score ?
65
PDB code
6bqv
Structure name
human trpm4 ion channel in lipid nanodiscs in a calcium-bound state
Structure deposition date
2017-11-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
17
Peptide accession
Q8TD43
Residue number A
993
Residue number B
1011
Peptide name
Transient receptor potential cation channel subfamily M member 4

Ligandability

Cysteine 993 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1011 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 4 between cysteines 299 and 311. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6bco
Structure name
cryo-em structure of trpm4 in atp bound state with short coiled coil at 2
Structure deposition date
2017-10-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
96
Peptide accession
Q7TN37
Residue number A
299
Residue number B
311
Peptide name
Transient receptor potential cation channel subfamily M member 4

Ligandability

Cysteine 299 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 311 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily M member 4 between cysteines 867 and 874. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6bqr
Structure name
human trpm4 ion channel in lipid nanodiscs in a calcium-free state
Structure deposition date
2017-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
39
Peptide accession
Q8TD43
Residue number A
867
Residue number B
874
Peptide name
Transient receptor potential cation channel subfamily M member 4

Ligandability

Cysteine 867 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 874 of Transient receptor potential cation channel subfamily M member 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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