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Hepatitis A virus cellular receptor 2

Intramolecular
Cysteine 52 and cysteine 63
Cysteine 58 and cysteine 109
Cysteine 38 and cysteine 110
Cysteine 63 and cysteine 109
Cysteine 58 and cysteine 63
Cysteine 52 and cysteine 109
Cysteine 109 and cysteine 110
Cysteine 58 and cysteine 110
Cysteine 38 and cysteine 58
Cysteine 52 and cysteine 58
More...
Cysteine 63 and cysteine 110
Cysteine 38 and cysteine 109
Cysteine 38 and cysteine 63
Cysteine 52 and cysteine 110
Cysteine 38 and cysteine 52
A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 52 and 63 (31 and 42 respectively in this structure).

Details

Redox score ?
83
PDB code
5f71
Structure name
human t-cell immunoglobulin and mucin domain protein 3 (htim-3)
Structure deposition date
2015-12-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
52
Residue number B
63
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 52 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 58 and 109.

Details

Redox score ?
79
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
58
Residue number B
109
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 58 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 38 and 110.

Details

Redox score ?
78
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
38
Residue number B
110
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 38 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 63 and 109 (42 and 88 respectively in this structure).

Details

Redox score ?
69
PDB code
7kql
Structure name
anti-tim3 antibody fab complex
Structure deposition date
2020-11-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
63
Residue number B
109
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 63 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 58 and 63 (36 and 41 respectively in this structure).

Details

Redox score ?
65
PDB code
6dhb
Structure name
crystal structure of the human tim-3 with bound calcium
Structure deposition date
2018-05-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
58
Residue number B
63
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 58 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 52 and 109 (31 and 88 respectively in this structure).

Details

Redox score ?
60
PDB code
7kql
Structure name
anti-tim3 antibody fab complex
Structure deposition date
2020-11-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
52
Residue number B
109
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 52 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 109 and 110 (88 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7m3y
Structure name
structure of tim-3 in complex with 8-chloro-2-methyl-9-(3- mehtylpyridin-4-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5(6h)-one (compound 22)
Structure deposition date
2021-03-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
109
Residue number B
110
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 109 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 58 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
58
Residue number B
110
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 58 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 38 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
38
Residue number B
58
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 38 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 52 and 58 (31 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5f71
Structure name
human t-cell immunoglobulin and mucin domain protein 3 (htim-3)
Structure deposition date
2015-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
52
Residue number B
58
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 52 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 63 and 110 (42 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
5f71
Structure name
human t-cell immunoglobulin and mucin domain protein 3 (htim-3)
Structure deposition date
2015-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
63
Residue number B
110
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 63 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 38 and 109. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
38
Residue number B
109
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 38 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 38 and 63. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6txz
Structure name
fab part of m6903 in complex with human tim3
Structure deposition date
2020-01-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
38
Residue number B
63
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 38 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 63 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 52 and 110 (31 and 89 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5f71
Structure name
human t-cell immunoglobulin and mucin domain protein 3 (htim-3)
Structure deposition date
2015-12-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
52
Residue number B
110
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 52 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hepatitis A virus cellular receptor 2 between cysteines 38 and 52 (16 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6dhb
Structure name
crystal structure of the human tim-3 with bound calcium
Structure deposition date
2018-05-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8TDQ0
Residue number A
38
Residue number B
52
Peptide name
Hepatitis A virus cellular receptor 2

Ligandability

Cysteine 38 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Hepatitis A virus cellular receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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