a tool for identifying drug-targetable redox-active disulphides

RB1-inducible coiled-coil protein 1

Intermolecular

Cysteine 1565 and cysteine 925

A redox-regulated disulphide may form between two units of RB1-inducible coiled-coil protein 1 at cysteines 1565 and 925 (1565 and 1479 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

crystal structure of nap1 fir in complex with rb1cc1 claw domain

Structure deposition date

2021-03-06

Thiol separation (Å)

8

Half-sphere exposure sum ?

53

Minimum pK_a ?

9

% buried

29

Peptide A name

RB1-inducible coiled-coil protein 1

Peptide B name

RB1-inducible coiled-coil protein 1

Peptide A accession

Peptide B accession

Peptide A residue number

1565

Peptide B residue number

925

Ligandability

Cysteine 1565 of RB1-inducible coiled-coil protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 925 of RB1-inducible coiled-coil protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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