ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RNA-directed DNA polymerase

Intramolecular
Cysteine 39 and cysteine 40
A redox-regulated disulphide may form within RNA-directed DNA polymerase between cysteines 39 and 40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2v0s
Structure name
crystal structure of a hairpin exchange variant (lr1) of the targeting line-1 retrotransposon endonuclease
Structure deposition date
2007-05-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
92
Minimum pKa ?
12
% buried
100
Peptide accession
Q8TE30
Residue number A
39
Residue number B
40
Peptide name
RNA-directed DNA polymerase

Ligandability

Cysteine 39 of RNA-directed DNA polymerase

Cysteine 40 of RNA-directed DNA polymerase

If this tool was useful for finding a disulphide, please cite: