ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MORC family CW-type zinc finger protein 4

Intramolecular
Cysteine 432 and cysteine 464
Cysteine 432 and cysteine 453
Cysteine 453 and cysteine 464
Cysteine 429 and cysteine 453
Cysteine 429 and cysteine 432
Cysteine 429 and cysteine 464
A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 432 and 464.

Details

Redox score ?
85
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
15
Peptide accession
Q8TE76
Residue number A
432
Residue number B
464
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 432 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 432 and 453.

Details

Redox score ?
84
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
6
% buried
24
Peptide accession
Q8TE76
Residue number A
432
Residue number B
453
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 432 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 453 and 464.

Details

Redox score ?
83
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
8
% buried
18
Peptide accession
Q8TE76
Residue number A
453
Residue number B
464
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 453 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 429 and 453.

Details

Redox score ?
80
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
8
% buried
34
Peptide accession
Q8TE76
Residue number A
429
Residue number B
453
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 429 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 453 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 429 and 432.

Details

Redox score ?
79
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
6
% buried
28
Peptide accession
Q8TE76
Residue number A
429
Residue number B
432
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 429 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 432 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MORC family CW-type zinc finger protein 4 between cysteines 429 and 464.

Details

Redox score ?
78
PDB code
7k7t
Structure name
crystal structure of human morc4 atpase-cw in complex with amppnp
Structure deposition date
2020-09-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
22
Peptide accession
Q8TE76
Residue number A
429
Residue number B
464
Peptide name
MORC family CW-type zinc finger protein 4

Ligandability

Cysteine 429 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of MORC family CW-type zinc finger protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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