ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Intramolecular
Cysteine 326 and cysteine 373
Cysteine 393 and cysteine 466
Cysteine 242 and cysteine 326 L
A redox-regulated disulphide may form within tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 between cysteines 326 and 373.

Details

Redox score ?
75
PDB code
5wwr
Structure name
crystal structure of human nsun6/trna/sfg
Structure deposition date
2017-01-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TEA1
Residue number A
326
Residue number B
373
Peptide name
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Ligandability

Cysteine 326 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 between cysteines 393 and 466.

Details

Redox score ?
65
PDB code
5wws
Structure name
crystal structure of human nsun6/trna/sam
Structure deposition date
2017-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
8
Peptide accession
Q8TEA1
Residue number A
393
Residue number B
466
Peptide name
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Ligandability

Cysteine 393 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 466 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 between cysteines 242 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
5wwr
Structure name
crystal structure of human nsun6/trna/sfg
Structure deposition date
2017-01-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
100
Peptide accession
Q8TEA1
Residue number A
242
Residue number B
326
Peptide name
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Ligandability

Cysteine 242 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 326 of tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: