a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase RNF128

Intramolecular

Cysteine 96 and cysteine 126

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF128 between cysteines 96 and 126.

Details

Redox score ?

85

PDB code

Structure name

protease-associated domain of the e3 ligase grail

Structure deposition date

2009-07-18

Thiol separation (Å)

3

Half-sphere exposure sum ?

48

Minimum pK_a ?

9

% buried

20

Peptide accession

Residue number A

96

Residue number B

126

Peptide name

E3 ubiquitin-protein ligase RNF128

Ligandability

Cysteine 96 of E3 ubiquitin-protein ligase RNF128

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of E3 ubiquitin-protein ligase RNF128

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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