DENN domain-containing protein 1A
Intramolecular
Cysteine 54 and cysteine 96
Cysteine 54 and cysteine 87
Cysteine 54 and cysteine 98
Cysteine 87 and cysteine 96
Cysteine 87 and cysteine 98
Cysteine 201 and cysteine 210
Cysteine 239 and cysteine 240
Cysteine 96 and cysteine 98
6ekk B 54 B 96
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 54 and 96.
Details
Redox score ?
82
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
2
% buried
100
Peptide accession
Q8TEH3
Residue number A
54
Residue number B
96
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 54 of DENN domain-containing protein 1A
Cysteine 96 of DENN domain-containing protein 1A
6ekk B 54 B 87
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 54 and 87.
Details
Redox score ?
81
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
95
Minimum pKa ?
2
% buried
100
Peptide accession
Q8TEH3
Residue number A
54
Residue number B
87
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 54 of DENN domain-containing protein 1A
Cysteine 87 of DENN domain-containing protein 1A
6ekk B 54 B 98
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 54 and 98.
Details
Redox score ?
80
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
98
Minimum pKa ?
2
% buried
100
Peptide accession
Q8TEH3
Residue number A
54
Residue number B
98
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 54 of DENN domain-containing protein 1A
Cysteine 98 of DENN domain-containing protein 1A
6ekk B 87 B 96
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 87 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
88
Minimum pKa ?
16
% buried
100
Peptide accession
Q8TEH3
Residue number A
87
Residue number B
96
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 87 of DENN domain-containing protein 1A
Cysteine 96 of DENN domain-containing protein 1A
6ekk A 87 A 98
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 87 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
94
Minimum pKa ?
16
% buried
100
Peptide accession
Q8TEH3
Residue number A
87
Residue number B
98
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 87 of DENN domain-containing protein 1A
Cysteine 98 of DENN domain-containing protein 1A
6ekk A 201 A 210
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 201 and 210. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
82
Peptide accession
Q8TEH3
Residue number A
201
Residue number B
210
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 201 of DENN domain-containing protein 1A
Cysteine 210 of DENN domain-containing protein 1A
6ekk B 239 B 240
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 239 and 240. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
82
Peptide accession
Q8TEH3
Residue number A
239
Residue number B
240
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 239 of DENN domain-containing protein 1A
Cysteine 240 of DENN domain-containing protein 1A
6ekk A 96 A 98
A redox-regulated disulphide may form within DENN domain-containing protein 1A between cysteines 96 and 98. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6ekk
Structure name
crystal structure of gef domain of dennd 1a in complex with rab gtpase rab35-gdp bound state
Structure deposition date
2017-09-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
15
% buried
100
Peptide accession
Q8TEH3
Residue number A
96
Residue number B
98
Peptide name
DENN domain-containing protein 1A
Ligandability
Cysteine 96 of DENN domain-containing protein 1A
Cysteine 98 of DENN domain-containing protein 1A
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