ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Guanine nucleotide exchange protein SMCR8

Intramolecular
Cysteine 314 and cysteine 644
A redox-regulated disulphide may form within Guanine nucleotide exchange protein SMCR8 between cysteines 314 and 644 (129 and 157 respectively in this structure).

Details

Redox score ?
65
PDB code
7el6
Structure name
structure of smcr8 bound fem1b
Structure deposition date
2021-04-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
96
Minimum pKa ?
8
% buried
100
Peptide accession
Q8TEV9
Residue number A
314
Residue number B
644
Peptide name
Guanine nucleotide exchange protein SMCR8

Ligandability

Cysteine 314 of Guanine nucleotide exchange protein SMCR8

Cysteine 644 of Guanine nucleotide exchange protein SMCR8

If this tool was useful for finding a disulphide, please cite: