Folliculin-interacting protein 1
Intermolecular
Cysteine 186 of Protein fem-1 homolog B and cysteine 608
Cysteine 186 of Protein fem-1 homolog B and cysteine 610
Cysteine 186 of Protein fem-1 homolog B and cysteine 613
Intramolecular
Cysteine 608 and cysteine 613
Cysteine 610 and cysteine 613
Cysteine 608 and cysteine 610
7roy C 186 H 580
A redox-regulated disulphide may form between cysteine 186 of Protein fem-1 homolog B and cysteine 608 of Folliculin-interacting protein 1 (186 and 580 respectively in this structure).
Details
Redox score ?
81
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
2
% buried
nan
Peptide A name
Protein fem-1 homolog B
Peptide B name
Folliculin-interacting protein 1
Peptide A accession
Q9Z2G0
Peptide B accession
Q68FD7
Peptide A residue number
186
Peptide B residue number
608
Ligandability
Cysteine 186 of Protein fem-1 homolog B
Cysteine 608 of Folliculin-interacting protein 1
7roy A 186 G 582
A redox-regulated disulphide may form between cysteine 186 of Protein fem-1 homolog B and cysteine 610 of Folliculin-interacting protein 1 (186 and 582 respectively in this structure).
Details
Redox score ?
76
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
nan
Peptide A name
Protein fem-1 homolog B
Peptide B name
Folliculin-interacting protein 1
Peptide A accession
Q9Z2G0
Peptide B accession
Q68FD7
Peptide A residue number
186
Peptide B residue number
610
Ligandability
Cysteine 186 of Protein fem-1 homolog B
Cysteine 610 of Folliculin-interacting protein 1
7roy C 186 H 585
A redox-regulated disulphide may form between cysteine 186 of Protein fem-1 homolog B and cysteine 613 of Folliculin-interacting protein 1 (186 and 585 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
22
% buried
nan
Peptide A name
Protein fem-1 homolog B
Peptide B name
Folliculin-interacting protein 1
Peptide A accession
Q9Z2G0
Peptide B accession
Q68FD7
Peptide A residue number
186
Peptide B residue number
613
Ligandability
Cysteine 186 of Protein fem-1 homolog B
Cysteine 613 of Folliculin-interacting protein 1
7roy H 580 H 585
A redox-regulated disulphide may form within Folliculin-interacting protein 1 between cysteines 608 and 613 (580 and 585 respectively in this structure).
Details
Redox score ?
88
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
2
% buried
59
Peptide accession
Q68FD7
Residue number A
608
Residue number B
613
Peptide name
Folliculin-interacting protein 1
Ligandability
Cysteine 608 of Folliculin-interacting protein 1
Cysteine 613 of Folliculin-interacting protein 1
7roy G 582 G 585
A redox-regulated disulphide may form within Folliculin-interacting protein 1 between cysteines 610 and 613 (582 and 585 respectively in this structure).
Details
Redox score ?
78
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
64
Peptide accession
Q68FD7
Residue number A
610
Residue number B
613
Peptide name
Folliculin-interacting protein 1
Ligandability
Cysteine 610 of Folliculin-interacting protein 1
Cysteine 613 of Folliculin-interacting protein 1
7roy H 580 H 582
A redox-regulated disulphide may form within Folliculin-interacting protein 1 between cysteines 608 and 610 (580 and 582 respectively in this structure).
Details
Redox score ?
78
PDB code
7roy
Structure name
the structure of the fem1b:fnip1 complex
Structure deposition date
2021-08-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
75
Minimum pKa ?
2
% buried
73
Peptide accession
Q68FD7
Residue number A
608
Residue number B
610
Peptide name
Folliculin-interacting protein 1
Ligandability
Cysteine 608 of Folliculin-interacting protein 1
Cysteine 610 of Folliculin-interacting protein 1
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