ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-MOG Z12 variable gamma 2a

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 165 and cysteine 208
A redox-regulated disulphide may form within Anti-MOG Z12 variable gamma 2a between cysteines 41 and 115 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
1q0y
Structure name
anti-morphine antibody 9b1 complexed with morphine
Structure deposition date
2003-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VDC9
Residue number A
41
Residue number B
115
Peptide name
Anti-MOG Z12 variable gamma 2a

Ligandability

Cysteine 41 of Anti-MOG Z12 variable gamma 2a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Anti-MOG Z12 variable gamma 2a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-MOG Z12 variable gamma 2a between cysteines 165 and 208 (142 and 208 respectively in this structure).

Details

Redox score ?
79
PDB code
1q0y
Structure name
anti-morphine antibody 9b1 complexed with morphine
Structure deposition date
2003-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VDC9
Residue number A
165
Residue number B
208
Peptide name
Anti-MOG Z12 variable gamma 2a

Ligandability

Cysteine 165 of Anti-MOG Z12 variable gamma 2a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Anti-MOG Z12 variable gamma 2a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 in protein B could not be asigned to a Uniprot residue.
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