a tool for identifying drug-targetable redox-active disulphides

Major prion protein

Intramolecular

Cysteine 179 and cysteine 214

A redox-regulated disulphide may form within Major prion protein between cysteines 179 and 214.

Details

Redox score ?

84

PDB code

Structure name

bank vole prion protein (121-231)

Structure deposition date

2008-06-26

Thiol separation (Å)

2

Half-sphere exposure sum ?

78

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

179

Residue number B

214

Peptide name

Major prion protein

Ligandability

Cysteine 179 of Major prion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of Major prion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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