ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Histone-lysine N-methyltransferase SETD7

Intermolecular
Cysteine 119 and cysteine 119
Intramolecular
Cysteine 303 and cysteine 318
A redox-regulated disulphide may form between two units of Histone-lysine N-methyltransferase SETD7 at cysteines 119 and 119.

Details

Redox score ?
71
PDB code
1xqh
Structure name
crystal structure of a ternary complex of the methyltransferase set9 (also known as set7/9) with a p53 peptide and sah
Structure deposition date
2004-10-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
9
% buried
72
Peptide A name
Histone-lysine N-methyltransferase SETD7
Peptide B name
Histone-lysine N-methyltransferase SETD7
Peptide A accession
Q8WTS6
Peptide B accession
Q8WTS6
Peptide A residue number
119
Peptide B residue number
119

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Histone-lysine N-methyltransferase SETD7 between cysteines 303 and 318. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3m56
Structure name
set7/9 y305f in complex with taf10-k189me2 peptide and adohcy
Structure deposition date
2010-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
94
Peptide accession
Q8WTS6
Residue number A
303
Residue number B
318
Peptide name
Histone-lysine N-methyltransferase SETD7

Ligandability

Cysteine 303 of Histone-lysine N-methyltransferase SETD7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Histone-lysine N-methyltransferase SETD7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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