GATOR complex protein NPRL2
Intermolecular
Cysteine 348 and cysteine 343 of GATOR complex protein NPRL3
Cysteine 286 and cysteine 343 of GATOR complex protein NPRL3
Cysteine 286 and cysteine 411 of GATOR complex protein NPRL3
Intramolecular
Cysteine 5 and cysteine 89
Cysteine 355 and cysteine 356
Cysteine 264 and cysteine 355
Cysteine 5 and cysteine 96 L
Cysteine 67 and cysteine 89
Cysteine 286 and cysteine 356
Cysteine 5 and cysteine 67
More...Cysteine 67 and cysteine 96 L
Cysteine 9 and cysteine 89
Cysteine 67 and cysteine 70
7t3c B 348 C 343
A redox-regulated disulphide may form between cysteine 348 of GATOR complex protein NPRL2 and cysteine 343 of GATOR complex protein NPRL3.
Details
Redox score ?
62
PDB code
7t3c
Structure name
gator1-rag-ragulator - dual complex
Structure deposition date
2021-12-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
4
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
348
Peptide B residue number
343
Ligandability
Cysteine 348 of GATOR complex protein NPRL2
Cysteine 343 of GATOR complex protein NPRL3
6cet N 286 M 343
A redox-regulated disulphide may form between cysteine 286 of GATOR complex protein NPRL2 and cysteine 343 of GATOR complex protein NPRL3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
46
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
286
Peptide B residue number
343
Ligandability
Cysteine 286 of GATOR complex protein NPRL2
Cysteine 343 of GATOR complex protein NPRL3
7t3b B 286 C 411
A redox-regulated disulphide may form between cysteine 286 of GATOR complex protein NPRL2 and cysteine 411 of GATOR complex protein NPRL3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7t3b
Structure name
gator1-rag-ragulator - gap complex
Structure deposition date
2021-12-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
90
Peptide A name
GATOR complex protein NPRL2
Peptide B name
GATOR complex protein NPRL3
Peptide A accession
Q8WTW4
Peptide B accession
Q12980
Peptide A residue number
286
Peptide B residue number
411
Ligandability
Cysteine 286 of GATOR complex protein NPRL2
Cysteine 411 of GATOR complex protein NPRL3
6cet N 5 N 89
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 5 and 89.
Details
Redox score ?
66
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
50
Peptide accession
Q8WTW4
Residue number A
5
Residue number B
89
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 5 of GATOR complex protein NPRL2
Cysteine 89 of GATOR complex protein NPRL2
6cet N 355 N 356
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 355 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
7
Half-sphere exposure sum ?
33
Minimum pKa ?
10
% buried
2
Peptide accession
Q8WTW4
Residue number A
355
Residue number B
356
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 355 of GATOR complex protein NPRL2
Cysteine 356 of GATOR complex protein NPRL2
6cet N 264 N 355
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 264 and 355. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
43
Minimum pKa ?
10
% buried
23
Peptide accession
Q8WTW4
Residue number A
264
Residue number B
355
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 264 of GATOR complex protein NPRL2
Cysteine 355 of GATOR complex protein NPRL2
6ces N 5 N 96
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 5 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
6ces
Structure name
cryo-em structure of gator1-rag
Structure deposition date
2018-02-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
42
Peptide accession
Q8WTW4
Residue number A
5
Residue number B
96
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 5 of GATOR complex protein NPRL2
Cysteine 96 of GATOR complex protein NPRL2
6cet N 67 N 89
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 67 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
60
Peptide accession
Q8WTW4
Residue number A
67
Residue number B
89
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 67 of GATOR complex protein NPRL2
Cysteine 89 of GATOR complex protein NPRL2
6ces N 286 N 356
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 286 and 356. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6ces
Structure name
cryo-em structure of gator1-rag
Structure deposition date
2018-02-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
10
% buried
20
Peptide accession
Q8WTW4
Residue number A
286
Residue number B
356
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 286 of GATOR complex protein NPRL2
Cysteine 356 of GATOR complex protein NPRL2
6cet N 5 N 67
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 5 and 67. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
44
Peptide accession
Q8WTW4
Residue number A
5
Residue number B
67
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 5 of GATOR complex protein NPRL2
Cysteine 67 of GATOR complex protein NPRL2
6cet N 67 N 96
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 67 and 96. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6cet
Structure name
cryo-em structure of gator1
Structure deposition date
2018-02-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
56
Peptide accession
Q8WTW4
Residue number A
67
Residue number B
96
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 67 of GATOR complex protein NPRL2
Cysteine 96 of GATOR complex protein NPRL2
7t3a B 9 B 89
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 9 and 89. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7t3a
Structure name
gator1-rag-ragulator - inhibitory complex
Structure deposition date
2021-12-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
39
Peptide accession
Q8WTW4
Residue number A
9
Residue number B
89
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 9 of GATOR complex protein NPRL2
Cysteine 89 of GATOR complex protein NPRL2
7t3b B 67 B 70
A redox-regulated disulphide may form within GATOR complex protein NPRL2 between cysteines 67 and 70. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7t3b
Structure name
gator1-rag-ragulator - gap complex
Structure deposition date
2021-12-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
64
Peptide accession
Q8WTW4
Residue number A
67
Residue number B
70
Peptide name
GATOR complex protein NPRL2
Ligandability
Cysteine 67 of GATOR complex protein NPRL2
Cysteine 70 of GATOR complex protein NPRL2
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