ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine/threonine-protein kinase 32A

Intermolecular
Cysteine 346 and cysteine 346
Cysteine 346 and cysteine 340
Cysteine 340 and cysteine 340
A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase 32A at cysteines 346 and 346.

Details

Redox score ?
74
PDB code
4fr4
Structure name
crystal structure of human serine/threonine-protein kinase 32a (yank1)
Structure deposition date
2012-06-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine/threonine-protein kinase 32A
Peptide B name
Serine/threonine-protein kinase 32A
Peptide A accession
Q8WU08
Peptide B accession
Q8WU08
Peptide A residue number
346
Peptide B residue number
346

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase 32A at cysteines 346 and 340.

Details

Redox score ?
63
PDB code
4fr4
Structure name
crystal structure of human serine/threonine-protein kinase 32a (yank1)
Structure deposition date
2012-06-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine/threonine-protein kinase 32A
Peptide B name
Serine/threonine-protein kinase 32A
Peptide A accession
Q8WU08
Peptide B accession
Q8WU08
Peptide A residue number
346
Peptide B residue number
340

Ligandability

Cysteine 346 of Serine/threonine-protein kinase 32A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of Serine/threonine-protein kinase 32A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Serine/threonine-protein kinase 32A at cysteines 340 and 340.

Details

Redox score ?
61
PDB code
4fr4
Structure name
crystal structure of human serine/threonine-protein kinase 32a (yank1)
Structure deposition date
2012-06-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide A name
Serine/threonine-protein kinase 32A
Peptide B name
Serine/threonine-protein kinase 32A
Peptide A accession
Q8WU08
Peptide B accession
Q8WU08
Peptide A residue number
340
Peptide B residue number
340

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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