a tool for identifying drug-targetable redox-active disulphides

Fibroblast growth factor receptor substrate 2

Intramolecular

Cysteine 61 and cysteine 80

A redox-regulated disulphide may form within Fibroblast growth factor receptor substrate 2 between cysteines 61 and 80.

Details

Redox score ?

74

PDB code

Structure name

nmr solution structures of frs2a ptb domain with neurotrophin receptor trkb

Structure deposition date

2013-10-18

Thiol separation (Å)

4

Half-sphere exposure sum ?

57

Minimum pK_a ?

8

% buried

48

Peptide accession

Residue number A

61

Residue number B

80

Peptide name

Fibroblast growth factor receptor substrate 2

Ligandability

Cysteine 61 of Fibroblast growth factor receptor substrate 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Fibroblast growth factor receptor substrate 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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