ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein Churchill

Intramolecular
Cysteine 30 and cysteine 61
Cysteine 2 and cysteine 30
Cysteine 5 and cysteine 30
Cysteine 88 and cysteine 91
Cysteine 30 and cysteine 33
Cysteine 30 and cysteine 64
Cysteine 33 and cysteine 61
Cysteine 33 and cysteine 64
Cysteine 2 and cysteine 5
Cysteine 61 and cysteine 64
More...
Cysteine 5 and cysteine 61
Cysteine 2 and cysteine 33
Cysteine 5 and cysteine 33
Cysteine 2 and cysteine 61
Cysteine 5 and cysteine 64
Cysteine 2 and cysteine 64
A redox-regulated disulphide may form within Protein Churchill between cysteines 30 and 61.

Details

Redox score ?
89
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
4
% buried
7
Peptide accession
Q8WUH1
Residue number A
30
Residue number B
61
Peptide name
Protein Churchill

Ligandability

Cysteine 30 of Protein Churchill

Cysteine 61 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 2 and 30.

Details

Redox score ?
89
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
4
% buried
nan
Peptide accession
Q8WUH1
Residue number A
2
Residue number B
30
Peptide name
Protein Churchill

Ligandability

Cysteine 2 of Protein Churchill

Cysteine 30 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 5 and 30.

Details

Redox score ?
89
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
4
% buried
18
Peptide accession
Q8WUH1
Residue number A
5
Residue number B
30
Peptide name
Protein Churchill

Ligandability

Cysteine 5 of Protein Churchill

Cysteine 30 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 88 and 91.

Details

Redox score ?
89
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
0
% buried
70
Peptide accession
Q8WUH1
Residue number A
88
Residue number B
91
Peptide name
Protein Churchill

Ligandability

Cysteine 88 of Protein Churchill

Cysteine 91 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 30 and 33.

Details

Redox score ?
89
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
4
% buried
4
Peptide accession
Q8WUH1
Residue number A
30
Residue number B
33
Peptide name
Protein Churchill

Ligandability

Cysteine 30 of Protein Churchill

Cysteine 33 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 30 and 64.

Details

Redox score ?
88
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
4
% buried
4
Peptide accession
Q8WUH1
Residue number A
30
Residue number B
64
Peptide name
Protein Churchill

Ligandability

Cysteine 30 of Protein Churchill

Cysteine 64 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 33 and 61.

Details

Redox score ?
86
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
4
Peptide accession
Q8WUH1
Residue number A
33
Residue number B
61
Peptide name
Protein Churchill

Ligandability

Cysteine 33 of Protein Churchill

Cysteine 61 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 33 and 64.

Details

Redox score ?
85
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
38
Minimum pKa ?
6
% buried
0
Peptide accession
Q8WUH1
Residue number A
33
Residue number B
64
Peptide name
Protein Churchill

Ligandability

Cysteine 33 of Protein Churchill

Cysteine 64 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 2 and 5.

Details

Redox score ?
83
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8WUH1
Residue number A
2
Residue number B
5
Peptide name
Protein Churchill

Ligandability

Cysteine 2 of Protein Churchill

Cysteine 5 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 61 and 64.

Details

Redox score ?
82
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
4
Peptide accession
Q8WUH1
Residue number A
61
Residue number B
64
Peptide name
Protein Churchill

Ligandability

Cysteine 61 of Protein Churchill

Cysteine 64 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 5 and 61.

Details

Redox score ?
64
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
18
Peptide accession
Q8WUH1
Residue number A
5
Residue number B
61
Peptide name
Protein Churchill

Ligandability

Cysteine 5 of Protein Churchill

Cysteine 61 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 2 and 33.

Details

Redox score ?
62
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
nan
Peptide accession
Q8WUH1
Residue number A
2
Residue number B
33
Peptide name
Protein Churchill

Ligandability

Cysteine 2 of Protein Churchill

Cysteine 33 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 5 and 33.

Details

Redox score ?
61
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
14
Peptide accession
Q8WUH1
Residue number A
5
Residue number B
33
Peptide name
Protein Churchill

Ligandability

Cysteine 5 of Protein Churchill

Cysteine 33 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 2 and 61. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
nan
Peptide accession
Q8WUH1
Residue number A
2
Residue number B
61
Peptide name
Protein Churchill

Ligandability

Cysteine 2 of Protein Churchill

Cysteine 61 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 5 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
14
Peptide accession
Q8WUH1
Residue number A
5
Residue number B
64
Peptide name
Protein Churchill

Ligandability

Cysteine 5 of Protein Churchill

Cysteine 64 of Protein Churchill

A redox-regulated disulphide may form within Protein Churchill between cysteines 2 and 64. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
2jox
Structure name
embryonic neural inducing factor churchill is not a dna-binding zinc finger protein: solution structure reveals a solvent-exposed beta- sheet and zinc binuclear cluster
Structure deposition date
2007-04-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
nan
Peptide accession
Q8WUH1
Residue number A
2
Residue number B
64
Peptide name
Protein Churchill

Ligandability

Cysteine 2 of Protein Churchill

Cysteine 64 of Protein Churchill

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