a tool for identifying drug-targetable redox-active disulphides

PRMT3 protein

Intramolecular

Cysteine 380 and cysteine 441

A redox-regulated disulphide may form within PRMT3 protein between cysteines 380 and 441.

Details

Redox score ?

69

PDB code

Structure name

human protein arginine methyltransferase 3 in complex with 1- isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea

Structure deposition date

2014-12-15

Thiol separation (Å)

5

Half-sphere exposure sum ?

74

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

380

Residue number B

441

Peptide name

PRMT3 protein

Ligandability

Cysteine 380 of PRMT3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 441 of PRMT3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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