ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

E3 ubiquitin-protein ligase TRIM41

Intramolecular
Cysteine 227 and cysteine 246
Cysteine 227 and cysteine 249
Cysteine 246 and cysteine 249
Cysteine 238 and cysteine 249
A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM41 between cysteines 227 and 246 (21 and 40 respectively in this structure).

Details

Redox score ?
87
PDB code
2egm
Structure name
solution structure of the zf-b_box domain from human tripartite motif protein 41
Structure deposition date
2007-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
54
Minimum pKa ?
6
% buried
2
Peptide accession
Q8WV44
Residue number A
227
Residue number B
246
Peptide name
E3 ubiquitin-protein ligase TRIM41

Ligandability

Cysteine 227 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 246 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM41 between cysteines 227 and 249 (21 and 43 respectively in this structure).

Details

Redox score ?
87
PDB code
2egm
Structure name
solution structure of the zf-b_box domain from human tripartite motif protein 41
Structure deposition date
2007-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
5
Peptide accession
Q8WV44
Residue number A
227
Residue number B
249
Peptide name
E3 ubiquitin-protein ligase TRIM41

Ligandability

Cysteine 227 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM41 between cysteines 246 and 249 (40 and 43 respectively in this structure).

Details

Redox score ?
76
PDB code
2egm
Structure name
solution structure of the zf-b_box domain from human tripartite motif protein 41
Structure deposition date
2007-03-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
6
Peptide accession
Q8WV44
Residue number A
246
Residue number B
249
Peptide name
E3 ubiquitin-protein ligase TRIM41

Ligandability

Cysteine 246 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase TRIM41 between cysteines 238 and 249 (32 and 43 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2egm
Structure name
solution structure of the zf-b_box domain from human tripartite motif protein 41
Structure deposition date
2007-03-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
5
Peptide accession
Q8WV44
Residue number A
238
Residue number B
249
Peptide name
E3 ubiquitin-protein ligase TRIM41

Ligandability

Cysteine 238 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of E3 ubiquitin-protein ligase TRIM41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: