ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

MIT domain-containing protein 1

Intermolecular
Cysteine 37 and cysteine 37
Cysteine 226 and cysteine 226
A redox-regulated disulphide may form between two units of MIT domain-containing protein 1 at cysteines 37 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4a5x
Structure name
structures of mitd1
Structure deposition date
2011-10-28
Thiol separation (Å)
6
Half-sphere exposure sum ?
93
Minimum pKa ?
13
% buried
100
Peptide A name
MIT domain-containing protein 1
Peptide B name
MIT domain-containing protein 1
Peptide A accession
Q8WV92
Peptide B accession
Q8WV92
Peptide A residue number
37
Peptide B residue number
37

Ligandability

A redox-regulated disulphide may form between two units of MIT domain-containing protein 1 at cysteines 226 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2ymb
Structure name
structures of mitd1
Structure deposition date
2012-10-08
Thiol separation (Å)
7
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
100
Peptide A name
MIT domain-containing protein 1
Peptide B name
MIT domain-containing protein 1
Peptide A accession
Q8WV92
Peptide B accession
Q8WV92
Peptide A residue number
226
Peptide B residue number
226

Ligandability

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