ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AN1-type zinc finger protein 2B

Intramolecular
Cysteine 115 and cysteine 118
Cysteine 115 and cysteine 134
Cysteine 105 and cysteine 123
Cysteine 100 and cysteine 105
Cysteine 100 and cysteine 123
Cysteine 118 and cysteine 134
Cysteine 100 and cysteine 118
A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 115 and 118 (30 and 33 respectively in this structure).

Details

Redox score ?
91
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
5
% buried
0
Peptide accession
Q8WV99
Residue number A
115
Residue number B
118
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 115 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 115 and 134 (30 and 49 respectively in this structure).

Details

Redox score ?
91
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
0
Peptide accession
Q8WV99
Residue number A
115
Residue number B
134
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 115 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 105 and 123 (20 and 38 respectively in this structure).

Details

Redox score ?
85
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
7
% buried
0
Peptide accession
Q8WV99
Residue number A
105
Residue number B
123
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 105 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 100 and 105 (15 and 20 respectively in this structure).

Details

Redox score ?
84
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
4
Peptide accession
Q8WV99
Residue number A
100
Residue number B
105
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 100 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 100 and 123 (15 and 38 respectively in this structure).

Details

Redox score ?
83
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
5
Peptide accession
Q8WV99
Residue number A
100
Residue number B
123
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 100 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 123 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 118 and 134 (33 and 49 respectively in this structure).

Details

Redox score ?
80
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
0
Peptide accession
Q8WV99
Residue number A
118
Residue number B
134
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 118 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AN1-type zinc finger protein 2B between cysteines 100 and 118 (15 and 33 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1x4v
Structure name
solution structure of the zf-an1 domain from human hypothetical protein loc130617
Structure deposition date
2005-05-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
4
Peptide accession
Q8WV99
Residue number A
100
Residue number B
118
Peptide name
AN1-type zinc finger protein 2B

Ligandability

Cysteine 100 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of AN1-type zinc finger protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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