a tool for identifying drug-targetable redox-active disulphides

Spindle and kinetochore-associated protein 2

Intermolecular

Cysteine 74 of Spindle and kinetochore-associated protein 1 and cysteine 79

A redox-regulated disulphide may form between cysteine 74 of Spindle and kinetochore-associated protein 1 and cysteine 79 of Spindle and kinetochore-associated protein 2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

crystal structure of the ska core complex

Structure deposition date

2012-02-15

Thiol separation (Å)

10

Half-sphere exposure sum ?

63

Minimum pK_a ?

10

% buried

16

Peptide A name

Spindle and kinetochore-associated protein 1

Peptide B name

Spindle and kinetochore-associated protein 2

Peptide A accession

Peptide B accession

Peptide A residue number

74

Peptide B residue number

79

Ligandability

Cysteine 74 of Spindle and kinetochore-associated protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Spindle and kinetochore-associated protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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