ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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tRNA-splicing endonuclease subunit Sen15

Intramolecular
Cysteine 81 and cysteine 91
A redox-regulated disulphide may form within tRNA-splicing endonuclease subunit Sen15 between cysteines 81 and 91 (47 and 57 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2gw6
Structure name
nmr structure of the human trna endonuclease sen15 subunit
Structure deposition date
2006-05-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
72
Peptide accession
Q8WW01
Residue number A
81
Residue number B
91
Peptide name
tRNA-splicing endonuclease subunit Sen15

Ligandability

Cysteine 81 of tRNA-splicing endonuclease subunit Sen15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of tRNA-splicing endonuclease subunit Sen15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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