ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gametocyte-specific factor 1

Intramolecular
Cysteine 51 and cysteine 71
Cysteine 17 and cysteine 37
A redox-regulated disulphide may form within Gametocyte-specific factor 1 between cysteines 51 and 71.

Details

Redox score ?
89
PDB code
6x46
Structure name
nmr solution structure of asterix/gtsf1 from mouse (chhc zinc finger domains)
Structure deposition date
2020-05-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
0
Peptide accession
Q9DAN6
Residue number A
51
Residue number B
71
Peptide name
Gametocyte-specific factor 1

Ligandability

Cysteine 51 of Gametocyte-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Gametocyte-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gametocyte-specific factor 1 between cysteines 17 and 37.

Details

Redox score ?
89
PDB code
6x46
Structure name
nmr solution structure of asterix/gtsf1 from mouse (chhc zinc finger domains)
Structure deposition date
2020-05-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
0
Peptide accession
Q9DAN6
Residue number A
17
Residue number B
37
Peptide name
Gametocyte-specific factor 1

Ligandability

Cysteine 17 of Gametocyte-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 37 of Gametocyte-specific factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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