ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Intelectin-1

Intramolecular
Cysteine 31 and cysteine 48
Cysteine 199 and cysteine 259
Cysteine 94 and cysteine 280
Cysteine 41 and cysteine 70
Cysteine 251 and cysteine 265
A redox-regulated disulphide may form within Intelectin-1 between cysteines 31 and 48.

Details

Redox score ?
90
PDB code
4wmq
Structure name
structure of human intelectin-1
Structure deposition date
2014-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WWA0
Residue number A
31
Residue number B
48
Peptide name
Intelectin-1

Ligandability

Cysteine 31 of Intelectin-1

Cysteine 48 of Intelectin-1

A redox-regulated disulphide may form within Intelectin-1 between cysteines 199 and 259.

Details

Redox score ?
84
PDB code
4wmy
Structure name
structure of human intelectin-1 in complex with allyl-beta- galactofuranose
Structure deposition date
2014-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WWA0
Residue number A
199
Residue number B
259
Peptide name
Intelectin-1

Ligandability

Cysteine 199 of Intelectin-1

Cysteine 259 of Intelectin-1

A redox-regulated disulphide may form within Intelectin-1 between cysteines 94 and 280.

Details

Redox score ?
81
PDB code
6usc
Structure name
structure of human intelectin-1 in complex with ko
Structure deposition date
2019-10-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WWA0
Residue number A
94
Residue number B
280
Peptide name
Intelectin-1

Ligandability

Cysteine 94 of Intelectin-1

Cysteine 280 of Intelectin-1

A redox-regulated disulphide may form within Intelectin-1 between cysteines 41 and 70.

Details

Redox score ?
81
PDB code
4wmy
Structure name
structure of human intelectin-1 in complex with allyl-beta- galactofuranose
Structure deposition date
2014-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WWA0
Residue number A
41
Residue number B
70
Peptide name
Intelectin-1

Ligandability

Cysteine 41 of Intelectin-1

Cysteine 70 of Intelectin-1

A redox-regulated disulphide may form within Intelectin-1 between cysteines 251 and 265.

Details

Redox score ?
80
PDB code
4wmy
Structure name
structure of human intelectin-1 in complex with allyl-beta- galactofuranose
Structure deposition date
2014-10-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8WWA0
Residue number A
251
Residue number B
265
Peptide name
Intelectin-1

Ligandability

Cysteine 251 of Intelectin-1

Cysteine 265 of Intelectin-1

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